Cytotoxicity Assays

Cytotoxicity assays are the animal-free test methods for evaluation of the toxic potential of substances in animals and man. Safety evaluation of compounds such as drugs, cosmetics, food additives, pesticides and industrial chemicals is increasing in numbers every year. The need for reliable, sensitive and quantitative assays enabling analysis of large numbers of compounds in preclinical research is therefore continuously rising.

IN CYTOTOX products offer a broad range of assays for the evaluation of cellular response to pharmaceutical or chemical compounds. They are based on well-established, sensitive and reliable endpoints of cytotoxicity and growth inhibition and are adapted for high throughput in microtiter plates.

The multiple endpoint IN CYTOTOX test kits allow the determination of up to four parameters from a single cellular sample. For example membrane integrity, cellular metabolism, mitochondrial activity and total protein synthesis or cell proliferation can be assessed from the same cells. The optimization of the combined kits increases the chances to detect cytotoxic effects, the data correlation of the tests, and reduces the overall handling time and the amount of test compounds needed. It enables optimal use of rare and valuable cell samples such as primary cells. Multiple endpoint kits also give hints to mechanisms of toxicity.

 

Available cytotoxicity test kits

• LDHE Extracellular Lactate Dehydrogenase

• NR Neutral Red

• SRB Sulforhodamine B

• XTT

 

Combinations for multiplexing

• PANI: LDHe-XTT-NR-SRB four parameter kit

 

Practical training and in-house testing of the cytotoxicity assays can be organized in the facilities of Xenometrix in Allschwil, Switzerland.

 

For detailed informatioin please visit our product catalog.

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